Wire them in parallel if, but only if, you really, really, really, really are certain that with them wired in series you hear clipping distortion, or else the volume isn't loud enough. If the volume is as loud as you want and you do not hear anything that sounds like amplifier clipping distortion, then you have no reason to wire them in parallel. [EDIT: I had to edit this and change that last word to parallel because I had suffered brain flatulence and had written series when I should have written parallel. Dammit.]
A given level of acoustic loudness (SPL) implies a corresponding level of acoustic power (even though the relationship between SPL and acoustic power is not linear), which means that for a given SPL (perceived loudness), you need a specific value for V x I. Power is also equal to V^2 / R. If they are wired in parallel, R is calculated (4 x 4)/(4 + 4) = 2; if they are wired in series R is 4 + 4 = 8. Since the ratio for R for the two alternatives is 8/2 = 4, this means that the ratio for V^2 will likewise be 4, and that the ratio for the amplifier output voltage will be 4^(1/2) = 2. Thus, for a given SPL (loudness), amplifier output voltage will be twice greater for series compared to parallel, whereas current will be twice greater for parallel compared to series.
If you decide that when wired in series the volume isn't as loud as you like when you can hear the amplifier clipping (or else it is clean but the gain control is fully up and it still isn't loud enough), then you wire in parallel, so that only half as much voltage is needed for a given loudness level. Current will be twice as great as it would be with series, and if this is a problem, the way that you will know that it is a problem is that the amplifier will get too hot and will shut down. Instead of shutting down completely it might do something else that will lower the output voltage in order to lower the current, but if it does this, it will not be subtle. In the worst case scenario you'll see smoke coming out it or you'll get a mild burn when you accidentally bump up against it. But you do not need to be concerned that sound quality is affected by the amplifier not being able to supply the amount of current implied by the output voltage in conjunction with the load impedance.