Rooms do not generate any sort of distortion generally unless there is something weird going on. Distortion is something that results from system nonlinearities, e.g. an amplifier that clips the tops off of a sine wave due to excessive drive. That will generate copious harmonics, and thus distortion. The room merely alters the frequency and time domain responses with its various modes, comb filtering, reverberation, etc.
For what it’s worth, typical quiet room has a background noise of about 30-35 dB on the A-weighted scale. If you are listening to music at 80 dB average, that puts your S/N ratio at about 50 dB. In reality since the audio is not stochastic (random), some details can be heard below the noise a bit, but still I would say once the SINAD of the equipment gets above 65 dB it’s no longer really a factor. With that in mind, though, the speakers will be the dominant source of distortion. If the electronics are good, then they can be regarded as “perfect” since they will be at least an order of magnitude better than most speakers. As such speakers and room treatment/corrections should be your primary focus.