To address the main point, I first start by saying that I understand them and that is normal to expect that any change in the chain to yield a difference, thing that I find normal. Afterwards, I start explaining how the differences that are present are so small that are indetectable by humans, the scale of them is below any threshold or any human outlier that they should be transparent if they are well designed and implemented. By first acknowledging the fact that they bothered to express their opinion and empathizing with them I have experienced that those that claim that there are "sound signatures" will be more open to listening to what you have to say and will value your feedback.
Even though I like science and use it to explain the world around me, I try to approach people as people with biases and opinion, without judging them for their lack of knowledge or their refusal to accept it, in the end, the best you can do is present the facts and let the other person take its own conclusion.