Using all the same speakers makes sense but it's not a requirement. I like Multi-channel Stereo as it gives me the option to listen to different speakers together. For instance, I have the Sierra Towers as my Fronts. They offer crystal clear sound but under 80Hz they are limited. I have two HSU subwoofers that reinforce the bottom. That would be where most people stop.
However, Multi-channel Stereo allows me to add other textures... so I am using 7' towers that have dual 15" drivers for extra thump in the bottom. With Multi-channel stereo you can drive any combination of speakers that you like or just go back to normal stereo. It's a powerful option for customizing my sound options.
All channel stereo is pretty awful it's the same signal to all speakers. Not recommended.
Use music surround type mode like pro logic iix music, or I use logic 7 music surround.
Also a good stereo integrated amplifier will outclass a good av amplifier. Typically avrs suck for music. They're ok for doing everything, but you know what they say jack of all trades master of none. A stereo integrated amplifier does one thing it doesn't have video scaling, hdmi inputs, noisy circuits, multiple amplifiers etc.
My audiolab 8000s outclass many av amps