Sorry I can´t help with that as I have SoundBlaster Command always running.
What´s your specs? CPU/RAM? Soundblaster Command is lighweight, IMO. You should not have any performance penalty for leaving it always running.
Since you have to switch modes for speakers/headphones, maybe you can try setting it to speakers and try to use your phone too see if SB Command are keeping your Speakers settings. You should not be able to use your phone with the panel set to speakers. If you can´t, maybe the panel are keeping your settings even when not running.
I just set mine to 24/192 for Speakers and Headphones, in Direct Mode. Sound´s good to me. Also, i´m running all analogic cables.
I think there´s no such thing as "Best Quality" in 32/384, as most music are 16/44.
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