I would imagine the effect would be both dynamic behaviour of the panels (to the mechanical and acoustic excitation) and size (ie surface area of cabinet) dependant so probably very much more important in large speakers.
I built a large 3-way pair of speakers (around 80 litres) when I was an impecunious student in 1970. I used chipboard because it was cheap and not that thick either, ⅜", around 10mm since I had to carry it home from the DIY shop.
The "feel" of the vibration on the panel surfaces didn't seem much less than the "feel" of the KEF B110 mid driver vibration given the much bigger surface area. I went on to do noise and vibration research for work and spent the next few years trying different ways to make the cabinets more inert as a hobby!
Each reduction sounded better to me, of course, but that could easily be expectation bias!
Back then I did have access to a computer (Imperial College had two and I was on a computing course which gave me access) but it is amusing, looking back, how far both hardware and software (and their price) have changed since then!
OTOH I did start writing my first software that earned me money then. There was no software one could buy, you wrote it yourself