but what science knows today can and will change entirely tomorrow
Pretty convinced you are trolling here, but just in case:
Yes, science evolves - but it doesn't throw out everything and start again. What we have observed in the past doesn't change. New observations that don't fit the model may come along, but then the model has to adapt to fit both old and new observations.
An example:
We have a limited understanding of how gravity actually works at the deep physical level. But we don't need that, to understand that if our leg is underneath a suspended anvil we don't want to release the rope.
We might one day improve our understanding and be able to develop an anti gravity machine. But the anvil/leg issue remains in the absence of said machine.
Similarly audio.
Audio is pretty much the simplest ever application of electronics. So much so, that it was the first application over 150 years ago. We've been doing it that long, we know how to do it, we know how it works. We know how to design it, we know how to measure it and we know what those measurements mean.
Everything we have scientifically measured, and tested about audio stands, and will not be reversed. Furthermore, audio signals are amongst the simplest of physical phenomena to measure. There is only amplitude, frequency and phase. And we have measurement equipment able to measure those to a sensitivity way beyond that of our ears.
You can measure
everything from a DAC or AMP that impacts the sound coming from the speakers. And therefore if there is a difference between the sound waves created by two different devices - reaching the subjects ear.