audiobill called it right on the D10 problem -- it is sleep-related. But it doesn't appear to be related to power.
If I put my Mac to sleep, the D10 display will initially show three hyphens (replacing the previously shown sampling rate). The hyphens will eventually be replaced by a single, dimly-lit decimal point. And that's all she wrote, sound-wise -- until a USB unplug/replug. Interestingly, querying the USB for a system report with the USB in that state shows that the D10 is still there as far as the system is concerned.
I tried this in both a USB 3.0 powered hub and directly connected to my iMac Pro's USB 3.0 port. The same behavior appeared on both, so it's not due to power going away.
I did some further testing, moving the D10 to my Windows 10 system (a DIY PC I built with a an AMD Ryzen) plugged into a motherboard-supplied USB 3.0 port. I also changed the USB cable at the same time. Sleeping the Windows 10 system results in identical behavior -- three hyphens eventually replaced by a single, dimly-lit decimal point. Waking the Windows 10 PC also does not bring the D10 back to life -- same as the Mac.
It looks like Topping has introduced an ugly bug that they need to fix.
Huh..
I would really ask Topping to send me previous version of the firmware to revert it back.